Three scientists shared the 2025 Nobel Prize in Physiology or Medicine for their contributions to the field of immunology. Earlier today, it was announced that Mary E. Brunkow, PhD, Fred Ramsdell, PhD, and Shimon Sakaguchi, MD, PhD, received this year’s award for fundamental discoveries relating to peripheral immune tolerance. The laureates identified and elucidated the activity of CD4+CD25+FOXP3+ regulatory T cells (Treg cells), which launched the field of Treg cell-mediated peripheral immune tolerance and forms the basis of efforts to develop new treatments for autoimmune disorders, cancer, and other applications.
